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2a–c), with JWU-A021 being the most potent (EC 50 1.9 μM)
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In Phase 3 clinical trials, anti-drug antibodies were detected in 3.0% to 7.0% of patients treated with albiglutide [122, 146, 149, 161, 162] and 2.2% of patients treated with dulaglutide [136]
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